Who is in ENDIA?

Who is in ENDIA?

We have had a close look at the characteristics of the wonderful people helping us to find the causes of type 1 diabetes. Our paper reports on who is in the ENDIA study and describes the demographics of parents, mother and baby’s health, and the genetic profiles related to type 1 diabetes risk.

ENDIA has 1,214 mothers who had 1,453 pregnancies, resulting in 1,473 babies over an 8-year period (2012-2020).

Over half of ENDIA children have a mother living with type 1 diabetes, a quarter have a father with T1D and 11% have a sibling living with the condition.

We found that mothers with type 1 diabetes experienced higher rates of pregnancy complications such as preeclampsia, premature birth, large babies for their gestational age, and interventions, such as inductions and caesarean sections.

Our ENDIA caregivers closely resemble the demographics of the Australian population, though a higher proportion were born in Australia, live in major cities, and have completed tertiary education.

These findings allow comparisons with similar international studies on early-life and type 1 diabetes risk. Notably, ENDIA provides valuable insights into how genetics and environmental factors interact to influence the development of type 1 diabetes.

The data and samples from the ENDIA cohort are seen as a significant global resource for understanding complex interactions and their implications for public health.

Access the full paper online at: https://drc.bmj.com/content/12/4/e004130